Yuqiang Wang Selected Research

tetramethylpyrazine

7/2021	The Tetramethylpyrazine Analogue T-006 Alleviates Cognitive Deficits by Inhibition of Tau Expression and Phosphorylation in Transgenic Mice Modeling Alzheimer's Disease.
1/2020	Neuroprotective and neurogenic effects of novel tetramethylpyrazine derivative T-006 in Parkinson's disease models through activating the MEF2-PGC1α and BDNF/CREB pathways.
12/2019	Novel neuroprotective tetramethylpyrazine analog T-006 promotes neurogenesis and neurological restoration in a rat model of stroke.
10/2019	Tetramethylpyrazine Analogue T-006 Promotes the Clearance of Alpha-synuclein by Enhancing Proteasome Activity in Parkinson's Disease Models.
1/2019	A Danshensu-Tetramethylpyrazine Conjugate DT-010 Overcomes Multidrug Resistance in Human Breast Cancer.
1/2019	Tetramethylpyrazine Nitrone Reduces Oxidative Stress to Alleviate Cerebral Vasospasm in Experimental Subarachnoid Hemorrhage Models.
1/2019	Tetramethylpyrazine Analogue T-006 Exerts Neuroprotective Effects against 6-Hydroxydopamine-Induced Parkinson's Disease In Vitro and In Vivo.
1/2018	A novel Danshensu/tetramethylpyrazine derivative induces vasorelaxation on rat aorta and exerts cardioprotection in dogs.
1/2018	Neuroprotective Effect and Mechanism of Action of Tetramethylpyrazine Nitrone for Ischemic Stroke Therapy.
1/2017	Synthesis and Biological Evaluation of Danshensu and Tetramethylpyrazine Conjugates as Cardioprotective Agents.

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Yuqiang Wang Research Topics

Disease

15	Parkinson Disease (Parkinson's Disease) 11/2021 - 07/2006
14	Ischemic Stroke 12/2019 - 10/2008
12	Neoplasms (Cancer) 01/2022 - 01/2001
11	Alzheimer Disease (Alzheimer's Disease) 07/2021 - 07/2006
10	Stroke (Strokes) 12/2019 - 10/2008
7	Myocardial Ischemia (Ischemic Heart Diseases) 02/2021 - 09/2013
7	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 07/2015
6	Inflammation (Inflammations) 12/2018 - 06/2015
4	Breast Neoplasms (Breast Cancer) 01/2019 - 01/2016
4	Leukemia 12/2015 - 01/2001
3	Hypertension (High Blood Pressure) 01/2022 - 01/2012
3	Colitis 01/2020 - 01/2016
3	Pain (Aches) 02/2019 - 09/2014
3	Cerebral Infarction 01/2018 - 10/2015
3	Infarction (Infarctions) 01/2018 - 11/2016
3	Myocardial Infarction 01/2018 - 06/2015
3	Mitochondrial Diseases (Mitochondrial Disease) 04/2017 - 05/2016
3	Leukemia L1210 01/2012 - 10/2005
2	Fibrosis (Cirrhosis) 01/2022 - 01/2021
2	Cognitive Dysfunction 07/2021 - 01/2017
2	Reperfusion Injury 02/2021 - 09/2017
2	Osteosarcoma (Osteogenic Sarcoma) 01/2021 - 12/2019
2	Traumatic Brain Injuries (Traumatic Brain Injury) 12/2019 - 11/2016
2	Neuralgia (Stump Neuralgia) 02/2019 - 01/2019
2	Spinal Cord Injuries (Spinal Cord Injury) 02/2019 - 01/2019
2	Acute Lung Injury 01/2019 - 06/2014
2	Body Weight (Weight, Body) 01/2019 - 10/2010
2	Intracranial Vasospasm 01/2019 - 01/2019
2	Cardiotoxicity 01/2019 - 01/2016
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 12/2017 - 01/2016
2	Cardiovascular Diseases (Cardiovascular Disease) 09/2017 - 08/2015
2	Hypoxia (Hypoxemia) 09/2017 - 01/2017
2	Wounds and Injuries (Trauma) 05/2017 - 01/2017
2	Neuroblastoma 01/2017 - 10/2016
2	Cerebrovascular Disorders (Cerebrovascular Occlusion) 02/2016 - 10/2015
1	Hematologic Neoplasms (Hematological Malignancy) 01/2022
1	Anemia 09/2021
1	Kyphosis 04/2021
1	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2021
1	Diabetic Nephropathies (Diabetic Nephropathy) 01/2021
1	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2021
1	Disease Progression 01/2021
1	Acute Kidney Injury (Acute Renal Failure) 01/2021

Drug/Important Bio-Agent (IBA)

16	Neuroprotective AgentsIBA 11/2021 - 10/2008
15	tetramethylpyrazineIBA 07/2021 - 06/2011
14	Pharmaceutical PreparationsIBA 07/2021 - 01/2001
10	tetramethylpyrazine nitroneIBA 01/2021 - 08/2012
10	Free RadicalsIBA 01/2019 - 10/2008
8	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2015
7	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2021 - 07/2006
7	3,4-dihydroxyphenyllactic acidIBA 01/2019 - 06/2015
7	Thymidine Monophosphate (TMP)IBA 01/2019 - 10/2008
6	DT-010IBA 02/2021 - 01/2016
6	Memantine (Namenda)FDA Link 01/2021 - 07/2006
6	Therapeutic UsesIBA 01/2021 - 08/2012
6	andrographolideIBA 01/2020 - 07/2009
5	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2022 - 06/2006
5	Ephrin-A5 (AL-1)IBA 01/2020 - 07/2014
4	NitratesIBA 01/2021 - 01/2017
4	CalciumIBA 07/2020 - 01/2014
4	EnzymesIBA 12/2017 - 01/2001
3	N-Methylaspartate (NMDA)IBA 01/2021 - 01/2019
3	Glutamic Acid (Glutamate)FDA Link 07/2020 - 01/2018
3	Biological ProductsIBA 12/2019 - 10/2016
3	Monoamine Oxidase (MAO)IBA 11/2017 - 01/2017
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2017 - 06/2015
3	ProdrugsIBA 07/2008 - 01/2001
3	CC 1065IBA 04/2003 - 01/2001
2	VimentinIBA 01/2022 - 11/2016
2	Antineoplastic Agents (Antineoplastics)IBA 01/2022 - 01/2002
2	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2020 - 10/2019
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2020 - 11/2018
2	ProteomeIBA 06/2019 - 02/2015
2	dehydrocorybulbineIBA 02/2019 - 01/2019
2	Purinergic P2X4 ReceptorsIBA 02/2019 - 01/2019
2	Trinitrobenzenesulfonic AcidIBA 01/2019 - 01/2016
2	LipopolysaccharidesIBA 01/2019 - 06/2014
2	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2019 - 10/2016
2	MEF2 Transcription FactorsIBA 11/2018 - 11/2017
2	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 11/2017 - 07/2014
2	Cholinesterases (Cholinesterase)IBA 04/2017 - 01/2017
2	Dopamine (Intropin)FDA LinkGeneric 01/2017 - 07/2014
2	chrysinIBA 07/2016 - 07/2015
2	AntioxidantsIBA 01/2016 - 07/2015
2	Peptides (Polypeptides)IBA 10/2015 - 02/2015
2	Amlodipine (Norvasc)FDA LinkGeneric 09/2014 - 09/2013
2	homocamptothecinIBA 01/2012 - 10/2005
1	Valsartan (Vals)FDA Link 01/2022
1	AnthracyclinesIBA 01/2022
1	CollagenIBA 01/2022
1	polydatinIBA 11/2021
1	Biomarkers (Surrogate Marker)IBA 09/2021
1	Ligases (Synthetase)IBA 01/2021
1	Amyloid (Amyloid Fibrils)IBA 01/2021

Therapy/Procedure

15	Therapeutics 02/2021 - 01/2001
1	Operative Time 04/2021
1	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/2021
1	Percutaneous Coronary Intervention 01/2021
1	Denervation 01/2021
1	Transcatheter Aortic Valve Replacement 01/2021